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Alienated is the sixth episode of the sixth season of Diagnosis Murder, and the one hundred sixteenth episode overall.
Jesse claims that he saw a flying saucer, which puts him in contact with a bunch of very spacey people and ultimately leads to murder.
DM's Star Trek salute features four cast members from the legendary series: Walter Koenig (Ensign Pavel Chekov), George Takei (Helmsman Hikaru Sulu), Majel Barrett (Nurse Christine Chapel), and Grace Lee Whitney (Yeoman Janice Rand), as well as Wil Wheaton (Wesley Crusher from Star Trek: The Next Generation) and Bill Mumy (Will Robinson from Lost in Space).