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Cañon City is the first episode of the twelfth season of ER, and the two hundred forty-seventh episode overall.
Guest Stars: Kyle Richards (Dori), Laura Ceron (Chuny), Troy Evans (Frank), Sara Gilbert (Jane Figler), Lynn A. Henderson (Olbes), Yvette Freeman (Haleh), Cristos (Kingsley), Kristen Fitzgerald (Judy), John Hoogenakker (Collins), Chris Kendrick (Deputy Two), Michael Krepack (Mason), Joey Miyashima (Deputy One), Alina Phelan (Mom), Jay Scorpio Powell (Canberra), Britain Spellings (Sackowitz), John Yoder (Elderly Man), Noel Arthur, Anastasia Basil, Damali Scott (Clemons), Corey Stoll (Teddy Marsh), John J. Acosta (Calima), Kent Avenido (Hong), William Charlton (Man), Emily Christine (Violet), Dominic Janes (Alex Taggart)
After Alex runs away from home to find his dad, Sam and Luka search for him; meanwhile, Abby, Ray and Neela have issues while in charge of the new interns.