Grey's Anatomy/Only the Strong Survive

Only the Strong Survive
Season 22, Episode 1
Airdate	October 9, 2025
Written by	Meg Marinis
Directed by	Debbie Allen
← 21x18 How Do I Live	22x02 → We Built This City
Grey's Anatomy — Season Twenty-Two

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Only the Strong Survive is the first episode of the twenty-second season of Grey's Anatomy, and the four hundred forty-ninth episode overall.

Starring: Ellen Pompeo (Dr. Meredith Grey), Chandra Wilson (Dr. Miranda Bailey), James Pickens, Jr. (Dr. Richard Webber), Kevin McKidd (Dr. Owen Hunt), Caterina Scorsone (Dr. Amelia Shepherd), Camilla Luddington (Dr. Jo Karev), Jason George (Dr. Ben Warren), Kim Raver (Dr. Teddy Altman), Chris Carmack (Dr. Atticus Lincoln), Anthony Hill (Dr. Winston Ndugu), Alexis Floyd (Dr. Simone Griffin), Harry Shum Jr. (Dr. Daniel "Blue" Kwan), Adelaide Kane (Dr. Jules Millin), Niko Terho (Dr. Lucas Adams), Trevor Jackson (Dr. Wes Bryant)

Guest Starring: Debbie Allen (Dr. Catherine Fox), Natalie Morales (Dr. Monica Beltran), Floriana Lima (Nora Young), Jade Pettyjohn (Dr. Dani Spencer), Micah McNeil (Security Guard Powell), Sophia Kopera (Dylan Gatlin)

Co-Starring: Amanda Joy Erickson (Lindsay Davis), Todd Denson (Mitchell Davis), Branden Silverman (ND Firefighter 1), David Lawrence (ND Firefighter 2), Jessica Rosilyn (Nurse Georgia), Deja Harris-Holmes (Intern 1)